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FPGEE Exam Dumps - Foreign Pharmacy Graduate Equivalency Examination

Question # 4

All are examples of antihelmintic drugs, EXCEPT:

A.

Niclosamide

B.

Prazinquatel

C.

Mebendazole

D.

Dapsone

E.

Thiabendazole

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Question # 5

Which of the following is NOT a side effect of tetracycline?

A.

Alteration in gut flora

B.

Disulfiram like reactions

C.

Teeth permanent discoloration

D.

Fanconi like syndrome

E.

Hyperchloremic metabolic acidosis

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Question # 6

All of the following are examples of amino penicillin, EXCEPT:

A.

Ampicillin

B.

Cloxacillin

C.

Amoxicillin

D.

Bicampicilin

E.

All are correct

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Question # 7

Which of the following is considered a polyene antifungal agent?

A.

Miconazole

B.

Clotrimazole

C.

Amphotericin

D.

Itraconazole

E.

Ketoconazole

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Question # 8

Which of the following statement is/are correct regarding Gray Babies syndrome?

I- Occurs in premature and new born infants when choramphenicol is administrated during the first few days of life

II- Due to inability of the infant to metabolize the drug because of glucoronyl transferase deficiency

III- Glucoronyl transferase is required to detoxify cloramphenicol

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

All are correct

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Question # 9

Drugs shown to be effective in the prevention of Travellers'

Diarrhea, which might have been prescribed for SM include:

I doxycycline

II cotrimoxazole

III amoxicillin

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

I, II and III

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Question # 10

Correct administration of Penicillamine in the treatment of rheumatois arthritis include:

A.

With meals

B.

In emptying stomach

C.

With plenty of water

D.

With orange juice

E.

Before bedtime

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Question # 11

The fraction of bound receptors in a well-defined drug-receptor binding system is determined by:

I the equilibrium drug-receptor dissociation constant

II the free drug concentration

III the total receptor concentration

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

I, II and III

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Question # 12

Tetrodotoxin is a selective inhibitor of the:

A.

calcium ion channel

B.

sodium ion channel

C.

potassium ion channel

D.

chloride ion channel

E.

nicotinic ion channel

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Question # 13

Which of the following is the most important vitamin in pregnancy?

A.

Cyanocobalamin

B.

Folic acid

C.

Pantothenic acid

D.

Pyridoxine

E.

Niacin

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Question # 14

Which of the following vitamin has its chemical structure related to PABA?

A.

Cyanocobalamin

B.

Folic acid

C.

Pantothenic acid

D.

Pyridoxine

E.

Niacin

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Question # 15

Which pyrimidine base is not present in DNA?

A.

Thiamine

B.

Adenine

C.

Uracil

D.

Cytosine

E.

Guanine

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Question # 16

Purine may be the end product of:

A.

Amines

B.

Amino acids

C.

Uric acid

D.

Proteins

E.

Enzymes

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Question # 17

Biological catalysts responsible for supporting almost all of the chemical reactions that maintain human life process:

A.

Nucleic acid

B.

Amino acids

C.

Carbohydrates

D.

Oligopeptides

E.

Enzymes

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Question # 18

Catabolism of carbohydrates is a process characterized by:

I- Consume of energy

II- Release stored energy from carbohydrates

III-Glycogenolysis is an example of carbohydrates catabolism reaction

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

All are correct

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Question # 19

Carotene is the precursor of:

A.

retinol

B.

thiamine

C.

calciferol

D.

riboflavin

E.

retinoic acid

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Question # 20

Which of the following amino acid is an important precursor of hemoglobin?

A.

Alanine

B.

Proline

C.

Leucine

D.

Glycin

E.

Histadin

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Question # 21

Vitamin that requires an intrinsic factor to be carried out to ileum in order to suffer absorption from the small intestine:

A.

Cyanocobalamin

B.

Folic acid

C.

Pantothenic acid

D.

Pyridoxine

E.

Niacin

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Question # 22

Abundant element in the interstitial fluid may include:

A.

Potassium

B.

Sodium

C.

Magnesium

D.

Calcium

E.

Chloro

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Question # 23

Which of the following is an antiviral drug used in the treatment of AIDS-HIV?

I- Acyclovir

II- Zidovudine

III- Stavudine

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

All are correct

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Question # 24

The conversion of β-carotene to vitamin A is carried out in:

A.

Pancreas

B.

Spleen

C.

Liver

D.

Adrenal cortex

E.

Nefrons

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Question # 25

Allopurinol, a xanthine oxidase inhibitor, is a derivative of:

A.

Uric acid

B.

Purine

C.

Pyridine

D.

Pteridine

E.

Urate salts

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Question # 26

The ethical principle of veracity requires that:

A.

we respect the rights of others to make choices.

B.

we act with honesty, without deception.

C.

we avoid, remove or prevent harm.

D.

we do good to patients.

E.

we act with fairness.

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Question # 27

In which of the following organs or tissues is the action of acetylcholine NOT described as "nicotinic"?

I Motor endplates of skeletal muscle

II Celiac ganglia

III Circular muscles of the iris

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

I, II and III

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Question # 28

The pharmacist fills a prescription for sumatriptan 100 mg tablets for a migraine patient. Appropriate information to provide to the patient includes which of the following?

A.

If the sumatriptan does not relieve the headache within four hours, ergotamine may be used.

B.

If no relief is achieved in two hours, sumatriptan may be repeated.

C.

If the headache is relieved but another headache occurs eight hours later, sumatriptan may be used for the second headache.

D.

The maximum dosage in any 24 hour period is six tablets.

E.

If relief is not achieved, no other medication can be used for 24 hours.

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Question # 29

Otitis media is an ear infection normally caused by S. pneumoniae and may be best treated by:

A.

Amoxicillin

B.

Penicillin V

C.

Ampicillin

D.

Amoxicillin clavulanate

E.

Oxacillin

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Question # 30

Potassium-sparing diuretics:

I exert their effect in the proximal tubule.

II may cause intracellular alkalosis.

III include the aldosterone antagonists.

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

I, II and III

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Question # 31

Class of tocainide is:

A.

Thiazides

B.

Antiarrhythmic agents

C.

Cephalosporins

D.

Autonomic nervous system drugs

E.

Beta blockers

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Question # 32

Diseases which are viral infections include:

I poliomyelitis

II rabies

III Legionnaires' disease

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

I, II and III

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Question # 33

Viral encephalitis, a CNS infection, may be best be treated by which of the following agents?

A.

Benzyl penicillin

B.

Ceftriaxone

C.

Acyclovir

D.

Streptomycin

E.

Vancomycin

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Question # 34

Which of the following is considered the FIRST precursor of vitamin A formation?

A.

Retinoic acid

B.

Carotenoids

C.

Cobalt

D.

Calciferol

E.

Pantothenic acid

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Question # 35

The only antibiotic available as chew able tablet includes:

A.

Penicillin

B.

Amoxicillin

C.

Ampicillin

D.

Erythromycin

E.

Clarithromycin

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Question # 36

Example of drug used in prophylaxis of malaria includes:

A.

Cloroquine

B.

Quinine

C.

Primaquin

D.

Quinine

E.

Quinidine

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Question # 37

Which of the following statements refers to pyrazinamide?

A.

Accumulates inside mycobacteria

B.

Effects: vasodilator in CHF patients; vasodilator and inotropic in normal individuals.

C.

Is active in acidic environment, therefore especially useful for killing intracellular mycobacteria

D.

Nephrotoxicity is almost always reversible.

E.

Lupus occurs more commonly in slow acetylators.

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Question # 38

Resistance is the major problem with penicillins due to ability of bacteria to breakdown the lactam ring of penicillin and inactivates the drug. To overcome these problem penicillins can be administrated together with β-lactamase inhibitors.

Examples of β-lactamase inhibitors is/are:

I- Clavulanic acid

II- Sulbactam

III- Tazobactam

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

All are correct

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Question # 39

Which of the following statements refers to carbamazepine?

A.

Effects in hypertension: 1. Blood pressure - decrease 2. Systemic vascular resistance - decrease 3. Heart rate - no change 4. Stroke volume - no change 5. Ejection fraction - no change 6. Venous capacitance - increase 7. Pulmonary capillary wedge pressure - no change 8. Renin - increase 9. Plasma aldosterone - decrease 10. Plasma norepinephrine - no change

B.

Cognitive side effects, respiratory depression.

C.

Generally very effective as a single drug.

D.

Few cognitive or behavioral side effects.

E.

Is found in breast milk.

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Question # 40

Half-life of tolbutamide is:

A.

12-24 hours

B.

3 hours

C.

6-12 hours

D.

10 hours

E.

8 hours

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Question # 41

Mechanism of action of FK506 is:

A.

Reduces calcium influx into neurons

B.

Inhibits calcineurin

C.

Inhibits phospholipase C

D.

Inhibits phospholipid synthesis

E.

Induces DNA damage under anaerobic conditions

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Question # 42

Which of the following is not directly related to a drug toxicity of Nitroglycerin?

A.

Headaches

B.

Tachycardia

C.

Dizziness

D.

Projectile vomiting

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Question # 43

Which of the following is considered a class IA Sodium Channel blocker?

A.

Mexiletine

B.

Aminodarone

C.

Quinidine

D.

Procainamide

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Question # 44

Mechanism of action of ampicillin is:

A.

Inhibits cholesterol synthesis

B.

Inhibits transpeptidase

C.

Inhibits viral DNA polymerase

D.

Potentiates glucose-mediated insulin secretion

E.

Inhibits renal epithelial Na channels

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Question # 45

Lansoprazole is not used in which of the following cases?

A.

Gastritis

B.

Peptic Ulcers

C.

Zollinger-Ellison syndrome

D.

Thalamus hypertrophy

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Question # 46

A drug ending in the suffix (navir) is considered a ______.

A.

Antidepressant

B.

Protease inhibitor

C.

Beta antagonist

D.

H2 antagonist

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Question # 47

Contraindication of sulfamethoxazole is:

A.

Gout

B.

Diabetes mellitus

C.

Hyperlipidemia

D.

Liver disease

E.

Late pregnancy

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Question # 48

Site of metabolism of zolpidem is:

A.

Liver

B.

None

C.

Reticuloendothelial system

D.

Leukocytes

E.

Unknown

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Question # 49

Which of the following is the antidote for the toxin Benzodiazepines?

A.

Flumazenil

B.

Methylene blue

C.

Deferoxamine

D.

Alkalinize urine

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Question # 50

Mechanism of action of vincristine is:

A.

Inhibits organification of iodine by thyroid gland

B.

Increases peripheral tissues sensitivity to insulin

C.

Reduces peripheral insulin resistance

D.

Inhibits Na-K-2Cl transporter

E.

Mitotic spindle poison

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Question # 51

Given F = .24, what is the overall hepatic clearance of morphine if the above patient has portal hypertension such that their hepatic blood flow is reduced by ½? Assume the clearance value given in the previous question is entirely hepatic clearance.

A.

30 L/hr/70 Kg

B.

60 L/hr/70 Kg

C.

120 L/hr/70 Kg

D.

250 L/hr/70 Kg

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Question # 52

Mechanism of action of flunisolide is:

A.

Inhibits DNA gyrase

B.

Inhibits phosphodiesterase

C.

Inhibits phospholipase A2

D.

beta-2 agonist

E.

Competitively inhibits H2 receptors

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Question # 53

Subclass of lomafloxacin is:

A.

Fluoroquinolones

B.

IA

C.

Calciferols

D.

Beta-lactamase resistant penicillins

E.

Aldosterone antagonists

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Question # 54

Which Cytochrome P450 isozyme does not participate appreciably in drug metabolism?

A.

CYP1A2

B.

CYP2C9

C.

CYP3A4

D.

CYP51

E.

All are drug metabolizing isoforms

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Question # 55

Mechanism of action of indinavir is:

A.

beta-2 agonist

B.

Inhibits RNA-dependent RNA polymerase

C.

Inhibits reverse transcriptase

D.

Inhibits viral protease

E.

Stimulates lipoprotein lipase

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Question # 56

Side effect of clindamycin is:

A.

Colitis (by Chlostridium difficili)

B.

Malabsorption

C.

Constipation

D.

Hypoglycemia

E.

Hepatotoxicity

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Question # 57

Biceps muscles are part of:

I the arm

II the thigh

III the rib cage

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

I, II and III

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Question # 58

Drug considered as the drug of choice in a specific asthma emergency treatment include:

A.

Salmeterol

B.

Adrenaline

C.

Albuterol

D.

Cortisone

E.

Zafirlukst

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Question # 59

Which is not a drug used for smoke cessation?

A.

Nicotine polacrilex

B.

Transdermal nicotine patches

C.

Nicotine sublingual tablets

D.

Bupropion

E.

Buspirone

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Question # 60

Condition characterized by a reversible form of airflow obstruction is known as:

A.

Aneurism

B.

Emphesema

C.

Embolism

D.

Cirrhose

E.

Jaundice

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Question # 61

The style of management in which the owner of a pharmacy emphasizes the development of detailed policies and written procedures for employees to observe at all times is referred to as:

A.

autocratic

B.

bureaucratic

C.

participative

D.

benevolent

E.

consultative

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Question # 62

Goals of gout treatment may include:

I- Reduce inflammation during acute attacks

II- Accelerate renal excretion of uric acid

III- Reduce the conversion of purine to uric acid

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

All are correct

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Question # 63

Autoimmune disorders include which of the following?

I Graves' disease

II Systemic Lupus Erythematosus

III Osteoarthritis

A.

I only

B.

III only

C.

I and II only

D.

II and III only

E.

I, II and III

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